2. Cell Cycle/DNA Damage Immunology/Inflammation
  3. Checkpoint Kinase (Chk) IFNAR
  4. Monalizumab

Monalizumab  (Synonyms: 莫那利珠单抗; IPH2201)

目录号: HY-P99032 纯度: 99.69%
COA

摩尔计算器

Monalizumab (IPH2201) 是一种靶向自然杀伤细胞群 2A (NKG2A) 的免疫检查点抑制剂。Monalizumab 是一种人源化抗 NKG2A 的单克隆抗体，可增加 IFN-γ 产生，从而促进自然杀伤细胞功能。Monalizumab 可用于头颈部鳞状细胞癌 (HNSCC) 的研究。

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CAS No. : 1228763-95-8

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1 mg ￥5300
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Monalizumab 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

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Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC)[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Monalizumab 阻断 NKG2A 并增强 CLL NK 细胞介导的针对表达 HLA-E 的 K562 细胞的细胞毒性[3]。
Monalizumab 增强 Enzalutamide (HY-70002) (10 μM) 诱导的 NK 细胞活化和杀伤前列腺癌细胞 (LNCaP 和 22Rv1)[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Monalizumab 相关抗体:
体内研究
(In Vivo)

Monalizumab (50 μg，瘤内注射，与 800 万个活化的 NK 细胞一起) 可有效抑制免疫缺陷小鼠异种移植 HLA-E+ 肿瘤的肿瘤生长[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4]
Dosage: 50 μg, together with 8 millions of activated NK cells
Administration: intratumoral injections
Result: Shows a synergestic antitumor effect.
Enhanced NK-cell killing, and induces lysis of tumor cells.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

莫那利珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料

纯度: 99.69%

COA (264 KB) SDS-PAGE (74 KB) SEC-HPLC (182 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Monalizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monalizumab1228763-95-8IPH2201莫那利珠单抗IPH 2201IPH-2201Checkpoint Kinase (Chk)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorCancer immunotherapyCD8 T cellsNK cellsNKG2AInhibitory immune receptorHLA-E/Qa-1head and neck squamous cell carcinomacancer immunotherapyimmune checkpoint inhibitorsrecurrent or metastaticInhibitorinhibitorinhibit

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